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Region: Midwest | West | East | South | Final 4 |
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| 2010 NCAA Men's Basketball Tournament Bracket - Midwest Region | ||||
| 1st Round | 2nd Round | Sweet 16 | Elite 8 | Final 4 |
| 1.) Kansas | ||||
| 90-74 (F)
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| 1.) Kansas | Midwest Region | |||
| 67-69 (F)
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| 16.) Lehigh | ||||
| 9.) Northern Iowa | ||||
| 8.) UNLV | 59-52 (F)
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| 66-69 (F)
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| 9.) Northern Iowa | ||||
| 9.) Northern Iowa | ||||
| 5.) Michigan State | ||||
| 5.) Michigan State | 70-69 (F)
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| 70-67 (F)
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| 5.) Michigan State | ||||
| 83-85 (F)
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| 12.) New Mexico State | ||||
| 5.) Michigan State | ||||
| 4.) Maryland | ||||
| 89-77 (F)
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| 4.) Maryland | ||||
| 13.) Houston | ||||
| 5.) Michigan State | ||||
| 6.) Tennessee | Champion (Midwest Region) |
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| 62-59 (F)
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| 6.) Tennessee | ||||
| 83-68 (F)
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| 11.) San Diego State | ||||
| 6.) Tennessee | ||||
| 3.) Georgetown | 73-76 (F)
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| 83-97 (F)
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| 14.) Ohio | ||||
| 14.) Ohio | ||||
| 6.) Tennessee | ||||
| 7.) Oklahoma State | ||||
| 59-64 (F)
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| 10.) Georgia Tech | ||||
| 75-66 (F)
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| 10.) Georgia Tech | ||||
| 2.) Ohio State | ||||
| 2.) Ohio State | ||||
| 68-51 (F)
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| 2.) Ohio State | Midwest Region | |||
| 15.) UC-Santa Barbara | ||||
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